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GBSSI and SSIIa were two major genes affecting AC and GC.
Two major genes affecting TG also present pleiotropic effects to HDL.
Chromosomes that explained most variance may also harbor the most important QTL (major genes) affecting the trait.
The results obtained with both methods consistently suggested the presence of major genes affecting ABT, X2, NTY, GTN and FTN.
Studies of major genes affecting polygenetic diseases will probably have a great impact on future dog breeding.
Moreover, Vallejo et al. (2009) and Quillet et al. (2010) reported a limited number of major genes affecting plasma cortisol levels after a crowding stress in rainbow trout.
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It was concluded that the CAPN1 gene was the major gene affecting the muscle fiber traits of chicken or was linked with the major gene.
In particular, the frequent use of half sibs and full sibs in animal studies increases the risk of falsely identifying genes as being differentially expressed, due to genetic linkage of the gene to a QTL or a major gene affecting the trait in question.
Apart from a large number of QTL reported on BAT14 [39], [51], [52], [52], the well-known DGAT1 gene[5] located at ∼0.44Mb is generally accepted as a major gene affecting milk production traits.
A subsequent study in 2004 [7], found that the evidence for a single major gene affecting the condition was not conclusive despite a heritability estimate for the phenotype of 0.73, and that this model did not completely explain the inheritance of inherited deafness in this breed.
Previous research identified IGF1 as a major gene affecting skeletal size in domestic dogs [ 16].
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