Sentence examples for major gene models from inspiring English sources

A common recessive allele with moderate penetrance had the best fit among the major gene models fitted for 'BRCA3'BRCA3

Table 3-wrap> summarizes the results for the major gene models for BRCA3 incorporating BRCA1 and BRCA2 mutations into the models but no allowance for polygenic effects.

The major gene models included a dominant, a recessive and a general model where the homozygous and heterozygous carriers were assumed to have different relative risks.

Among the major gene models fitted, the recessive model was the most parsimonious, and a recessive effect was also found by Cui et al (2001) in BRCA1/2 negative families.

However, the evidence for a major gene is weakened by the fact that the contribution of the 'B' families to the overall log-likelihood is always smaller under the major gene models for BRCA3 than their contribution under the sporadic model.

Sporadic or no major gene model.

These results suggest that a major gene model underlies the aetiology of oesophageal cancer in these families.

The major gene model was favoured, and the sporadic and multifactorial models were strongly rejected.

Two extreme architectures have been traditionally considered: (1) a major gene model in which a few genes explain most of the genetic variance and (2) the infinitesimal model.

When a clear major gene model can be inferred and reliable epidemiologic information is collected (e.g., in schistosomiasis), parametric linkage studies are used.

In addition, we also did simulations starting from no initial genetic variation for male nuptial coloration at all (i.e., the results for our one locus major gene model), which yielded similar speciation probabilities as our other models.