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Unfortunately, however, segregation analysis tends to be weak at discrimating models unless there is a clear major gene component.
Previous segregation analyses (eg [ 21]) were quite successful at identifying a major gene component responsible for a subset of cases, consistent with the effects of BRCA1 and BRCA2.
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To analyze the telomerase activation on the gene level, the mRNA expression of three major gene components of the telomerase, hTERT, hTR and TEP-1, in the passages cells was observed (Fig. 7).
In the third major category of cellular component, the major gene changes were in the cell, cell part, followed by the organelle, and extracellular part subcategories.
Three major gene profiles were generated by Principal Component Analysis (PCA).
"GO System" represents the major gene ontological system (i.e., cellular component, biological process, or molecular function).
Sporadic or no major gene model.
Major gene without familial association model.
There were three major gene clusters.
This down-regulation occurred in all major genes of the pyruvate dehydrogenase complex, namely, dihydrolipoamide S-acetyltransferase (DLAT), component X (PDHX) and component beta (PDHB) (Table 4).
HGPS is an extremely rare genetic disease caused by a de novo point mutation in the lamin A (LMNA) gene, a major structural component of the nuclear envelope [ 43].The pathogenic mutation leads to the production of an internally truncated form of lamin A, referred to as progerin.
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