In the females on 20% CR the major functional gene pathway that was significantly up-regulated was the glycolysis pathway.
The genes selected for qRT-PCR confirmation were those representing the major functional gene families among the downregulated genes.
Indeed, major functional gene categories that were specifically up-regulated in cisplatin-treated OC spheroids included cellular assembly and organization, cell death and DNA replication, recombination, and repair.
In the 8 hours post-infection group, major functional gene categories were especially up-regulated by Salmonella infection including DNA replication, recombination and repair, cellular assembly and organization, cellular function and maintenance, and metabolism.
As seen from Table 4, up-regulated major functional gene groups comprised genes mostly involved in cell growth and proliferation, control of cell cycle (including cell cycle arrest) and DNA replication and repair.
In the 4 days post-infection group, major functional gene categories that were specifically up-regulated in Salmonella infection included cell-to-cell signaling and interaction, cellular movement, cellular development, antigen presentation, cell death, cellular growth and proliferation, and cellular function and maintenance.
We propose that VvAGL11 is the major functional candidate gene for seedlessness, and we provide experimental evidence suggesting that the seedless phenotype might be caused by variations in its promoter region.
Polyphenol oxidases are the major functional candidate genes for the enzymatic browning reaction.
In some major functional groups, genes were further separated into subcategories to simplify the data for biological interpretation [see Additional file 1].
The analysis detected the presence of two major functional categories - genes involved in brain development and starch metabolism.
Major functional categories of genes up- and down-regulated by heat stress.
