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In RA, the sustained inflammatory process progressively destroys the articular cartilage and subchondral bone leading, in many cases, to major functional disability [1].
Contrary to the delayed peak of fever, secondary hypomobility was not transient and resulted in a major functional disability (-80% at day 17).
Long-term disease can lead to major functional disability; therefore, early diagnosis and determination of risk factors are important in effective disease management.
Generally, however, patients with SMD, who are burdened with chronic disease and major functional disability, need substantial help from various resources on a long-term basis to meet their multiple bio-psycho-social needs [ 14].
Subjects were eligible if they had been discharged from hospital, had a HARRPE score ≥0.4, or had a major functional disability as clinically indicated, and were being supported by home carers who were living with the patients.
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Damage of central WM is a major cause of functional disability in cerebrovascular disease; the majority of ischaemic strokes involve both WM and GM (Goldberg and Ransom, 2003; Hamner et al., 2011).
As mentioned above, pain is the major determinant in functional disability caused by OA [ 40].
Both diabetes and depression were major contributors of functional disability in the elderly population [ 7].
Osteoarthritis (OA) of the hip is a major cause of functional disability and reduced quality of life.
Because all of the above conditions are major causes of functional disability (14– 16), it is expected that green tea consumption would contribute to disability prevention.
The probability to be free from a major and permanent functional disability has been modelled in the 52 weeks before death using life-table statistical analysis.
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