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There is presently no consensus regarding whether differences in ion channels and receptors, that constitute the major functional differences between neurons, are subject to active regulation at the transcriptional level.
While the pathway completeness-based analysis can highlight major functional differences between metagenomes and reference genomes, it does not account for the abundance of specific genes, and thus does poorly in differentiating relatively similar communities (e.g. the three archaeal communities).
This suggests that there are no major functional differences relating to cell movement between the exogenous and endogenous proteins.
The major functional differences between Sti1 and Hop observed in this study are conveyed by phosphorylation which occurs almost exclusively at unique sites.
In spite of the large difference in genomic occupancy, detailed analysis of genes associated with GATA3 binding failed to identify any major functional differences between binding profiles in T47D and MCF7 cell lines (Additional file 1: Figure S6-S10).
This small degree of overlap suggests major functional differences between Brc1 and Rtt107 despite their similarities in domain organization and a shared mechanism of localizing to DNA lesions through C-terminal BRCT domains binding γH2A (Li et al. 2012; Williams et al. 2010).
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Running a second ANOVA on the unsigned magnitudes of the deviations (Table 1, right panel; cf. Fig. 4, dashed lines) shows no main effect on either variable, but reveals a highly significant interaction between them that indicates a major functional difference between the two brainstem zones analyzed.
The major functional difference between NANOG and NANOGP8 is at the level of gene expression.
The neoplastic transforming activity is the role of the mt-PCPH that represents the major functional difference between the normal protooncogene and mutated active oncogene.
Thus, a major functional difference between OCRL and INPP5B seems to be the involvement of OCRL, but not of INPP5B, in clathrin-mediated endocytosis.
The alternative splicing of this exon suggests a major functional difference between the two TACC2 isoforms, TACC2s and TACC2l [ 3], as well as a significant difference between TACC2 and its closest TACC family relative, TACC1.
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