"major fluctuation" is correct and usable in written English.
You can use it to describe a large or sudden change in something, such as a change in a stock market index. For example: "There was a major fluctuation in the price of oil this week."
"We've seen the rate of exchange experience major fluctuation.
In addition, McManus et al. reported that the muscle glycogen levels when inhibiting GSK-3 did not cause major fluctuation when comparing to control in GSK-3 knock-in animals22.
Moreover, there was no major fluctuation in the network lifetime due to the increase of the number of sensor nodes.
The goal of the article is to develop an algorithm to determine the shift velocity (the phase speed of the major fluctuation component), the sweeping velocity, and the sense of wavevector anisotropy using the measurement of the energy spectrum in the wavevector frequency domain.
Graham et al. observed no major fluctuation in serum total calcium during menstruation in six patients with post surgical hypoparathyroidism.
In an optimization procedure, good circuits should be able to reproduce the patterns as well as the shift without showing any major fluctuation of the gap gene expression while varying the Bcd concentration.
In 2007 and 2008, the reservoir filled, with major fluctuations in the water level.
"Given such a large population base, there would be major fluctuations in population growth if we abandoned the one-child rule now," he said.
Coffee rust: Over recent years, Nicaragua's specialty coffee farmers say they have witnessed major fluctuations in humidity, precipitation and temperature levels.
While energy consumers in states like Colorado, Wyoming and Montana, where prices have more than doubled, would welcome a such a low increase, Idahoans are unaccustomed to major fluctuations.
Periodic changes in the heat received from the Sun, caused by fluctuations in the Earth's orbit, are known to correlate with major fluctuations of ice sheet advance and retreat on long time scales.
