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While this forms the major feedback loop of the mammalian molecular clock, the overall mechanism also depends on additional feedback loops driven by ROR and REV-ERBα/β (Preitner et al., 2002; Sato et al., 2004; Ueda et al., 2005; Cho et al., 2012).
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These two models were compared concerning their prediction quality and their analytical power: One model allowed easy identification of the major feedback loops governing the swarm behavior.
EIN3 binding also controlled a multitude of downstream transcriptional cascades, including a major negative feedback loop.
Therefore, MDM2 induction in response to p53 is the major negative feedback loop aimed at blocking p53 proapoptotic function and thus allowing cell survival (Malaguarnera et al, 2007).
Three major interlocked feedback loops constitute the plant circadian clock: the central loop, the morning loop, and the evening loop [ 3- 5].
The major function of the feedback loop is to process the camera image of the workspace and output data on the OFB microrobots and the micro-objects under manipulation.
KCa2 channels may, therefore, have a major role in the regulatory feedback loop that interrupts the glutamate-triggered neuronal hyperexcitability, progressive disturbance of Ca2+ homeostasis and excitotoxic neuronal death.
Taken together, these results indicate that L11 is a major inhibitor of the MDM2-p53 feedback loop in response to ribosome stress.
By contrast, the Qrr-LuxO feedback loop is the major source of dosage compensation for qrr4.
This feedback loop also allows any major faults or warnings to be instantly relayed to Acura so that the fault can be analyzed.
Second, the direct interaction between peers (reciprocity) plays a major role, especially if there's a transparent feedback loop.
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