Obesity is a major factor for the development of diabetes mellitus type 2 and the number of obese subjects increases especially in industrial countries.
Hyperglycemia is a major factor for the development of diabetic cardiomyopathy (DCM) which contributes substantially to morbidity and mortality [ 5- 7].
Although neurofibrillary degeneration may appear early in life [ 9], aging is one major factor for the development of AD-related neuropathology.
Diabetes is often linked with abnormal lipid metabolism and is considered as a major factor for the development of atherosclerosis and cardiovascular complication [ 15].
A major factor for successful game development is the adequate control of the game׳s difficulty.
Estrogen exposure is considered a major risk factor for development of breast cancer and the majority of breast cancers maintain their hormonal dependency [ 12, 13].
Hypertension (high blood pressure) is a major risk factor for development of cardiovascular diseases.
The major risk factor for development of AIDS was being older at time of HIV infection and for death was not receiving HAART (Table S1).
Older age is the major risk factor for development of CVD [ 1].
Hypertension is a major risk factor for development and progression of chronic kidney disease [ 1].
