Sentence examples for major extent by from inspiring English sources

Dan Jinks and Bruce Cohen, who produced "American Beauty," the film that most here expect to win the most Oscars this year, say they have no doubt that the critical and box office success of their film was driven to a major extent by this new craving for surprise and originality in movie audiences.

The similarity in long-term Fe(II) partitioning in these samples suggests that the effects of HA are mostly kinetic, and that the thermodynamics of Fe(II) sorption are not affected to a major extent by the presence of HA.

Here, we show that PARP activity during photoreceptor neurodegeneration is caused to a major extent by the PARP1 isoform specifically.

The observed relations were of modest magnitude, and the relations of TIMP-1 to stroke risk were not explained to any major extent by established cardiovascular disease risk factors or C-reactive protein.

This reaction is catalysed to a major extent by CYP2D6 [ 12, 24].

Deer at low population densities on natural range are less likely to be affected to any major extent by disease.

We conclude that the present formulation of [11C]DHTP (22.1% ±4.7% deuterated) is still to a major extent degraded by MAO-A in non-human primates and that the secondary KIE introduced by a partial deuteration of the β-position has only a minor effect on the stability of [11C]DHTP against this enzyme despite promising results in cells and in rodents.

This response depends on the balanced activation and subsequent attenuation of signaling pathways linked to the G-CSFR, which is to a major extent controlled by lysosomal routing of the activated G-CSFR complex [2], [3].

It has been reported that the intracellular uptake is to a major extent determined by the carrier ligand [ 15, 18].

The reason for comparing the expression profile in both cell types is that retinoid receptors are to a major extent expressed by keratinocytes in suprabasal layers of epidermis [ 25, 36], suggesting that retinoids may affect gene transcription mainly in differentiated cells.

To the major extent it is caused by difficulties in obtaining suitable samples.