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The major experimental challenge is to control the spin fluctuation to within a threshold value, which is achieved by developing a set of optimized GRAPE pulse sequences.
Phenotypic high-throughput chemical screens allow for discovery of small molecules that modulate complex phenotypes and provide lead compounds for novel therapies; however, identification of the mechanistically relevant targets remains a major experimental challenge.
The major experimental challenge involved in designing such an assay is the apparent conflict between the rapid acquisition of vast amount of migration data, and the need to obtain "high content" information about the migratory behavior of many cells, including dynamic features such as migration velocity and lamellipodial activity.
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There are though two major experimental challenges that need to be dealt with for toxicogenomics to be successful.
There are also some major experimental challenges or choices that need to be carefully navigated to unearth the mechanisms governing the chemical degradation behavior and kinetics of boron-containing bioactive glasses, and to accurately determine the composition structure property relationships.
Elucidation of a unifying mechanism underlying CMT caused by mutations at multiple sites within four ARSs remains a major intellectual and experimental challenge.
In particular, the major experimental and analytical challenges encountered (and inferred to result from so-called "nanonugget" formation) are described.
Surrealist painter Salvador Dalí designed three major experimental ballets.
HA performed major experimental work.
YL performed major experimental work.
GF supervised experimental challenges and sample collection.
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CEO of Professional Science Editing for Scientists @ prosciediting.com