The idea that processes can have such dual effects is consistent with a major evolutionary theory termed antagonistic pleiotropy by Williams GC.
The idea that a biological process such as cellular senescence can be both beneficial (tumor suppressive) and deleterious (pro-tumorigenic) is consistent with a major evolutionary theory of aging termed antagonistic pleiotropy [ 24].
How can TEs be integrated as a major evolutionary factor in Darwinian theory?
With his knack for getting across complex ideas by means of gripping examples, Jones uses the history of HIV to illustrate all the major points of evolutionary theory in just a few pages.
Though a major expositor of evolutionary theory, Dr. Williams was always aware that his explanations were a work in progress and that they might in principle be superseded by better ones.
Understanding how mutation, selection, and genetic drift drive this process, and uncovering the structure of the fitness landscape from genomic data are two major goals of evolutionary theory.
Modularity theory [22], [23] and a reexamination of mutationism in the light of modern morphogenetics [24], have opened the door to a major revision of evolutionary theory to accommodate this new understanding of body plan innovation.
One of the major aspects of evolutionary theory that evo-devo failed to integrate so far is the link between developmental genetic mechanisms and the evolutionary history of the phenotype [ 10, 11, 22, 23].
Because the vast size of the real spaces is a major part of the problem that evolutionary theories must grapple with, models that capture this close the gap to nature in a significant respect.
A recent theory proposes that, during major evolutionary transitions, evolution is biphasic, further complicating the model of protein evolution [ 7].
