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Hepatitis E virus (HEV) is the major etiologic agent of enterically transmitted viral hepatitis in much of the developing world.
Rotavirus can be regarded as a major etiologic agent of acute diarrhea in infants and children up to 5-years-old in Iran, immunization at birth may protect the children before their first symptomatic infection.
It is considered the major etiologic agent of chronic active gastritis and is generally accepted as the primary cause of peptic ulcer disease; it is also a known risk factor for gastric cancer [2].
As better diagnostic assays become commercially available, this pathogen is now recognized also as a major etiologic agent of sporadic acute hepatitis in endemic countries and autochthonous acute hepatitis cases in Western Europe and industrialized countries of East Asia [1], [8].
The Gram-negative species Aggregatibacter actinomycetemcomitans is a major etiologic agent of human periodontitis.
Hepatitis E virus (HEV) represents the major etiologic agent of enterically transmitted, non-A, non-B hepatitis.
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Group A rotaviruses are the major etiologic agents of severe infantile diarrhea.
The relative importance of major etiologic agents responsible for diarrhea is not well established in Ethiopia.
S. sonnei is one of the major etiologic agents of travel-associated diarrhoea [ 22].
Mutans streptococci (Streptococcus mutans and S. sobrinus) are considered to be major etiologic agents of dental caries in humans [ 1– 3].
Enteric viruses are major etiologic agents of acute gastroenteritis (AGE) among infants and young children worldwide (1 ).
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