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It is a major episode with widespread damage.
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This is not supported by our study: only 23% (34 of 148) of all major episodes with detemir and 28%6666 of 237) with NPH were nocturnal.
The aim of the present study is to identify the potential predictors of infections in a prospective observational cohort of patients with SLE, limiting the analysis to major episodes with important clinical impact and including antimalarials among the potential variables influencing the final outcome.
The reference criteria were "current major depressive episode" or "current major depressive episode with major depressive disorder".
The DSM-IV-TR diagnoses of "current major depressive episode" and "current major depressive episode with major depressive disorder" were the criterion standard.
For this reason, we compared the operational characteristics of PHQ-9 against "current major depressive episode" and "current major depressive episode with major depressive disorder".
Compared with false-positive cases for the PHQ-9 diagnostic algorithmic threshold against "current major depressive episode", the number of those against "current major depressive episode with major depressive disorder" increased by 7 patients.
For "current major depressive episode with major depressive disorder", PHQ-9 also showed high sensitivity and high negative predictive value at both thresholds, but the positive predictive value decreased more than that for "current major depressive episode".
Our analysis of the validity of PHQ-9 for the screening for current major depressive episode with major depressive disorder (Table 2) revealed that the positive predictive value decreased by about 10%% compared with the screening for current major depressive episode.
This tendency was particularly pronounced for the threshold of the summary score of PHQ-9 ≥10 Table 2 (right half) presents operating characteristics of PHQ-9 for "current major depressive episode with major depressive disorder" for the PHQ-9 diagnostic algorithmic threshold and for the cut-off point (threshold) of summary score of PHQ-9 ≥10.
A more interesting case develops when a cooled older crust is fractured, invaded by a swarm of dikes, and subsequently subjected to a major episode of heating with deformation and intrusion of new magma.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com