Sentence examples for major epigenetic modification from inspiring English sources

Epigenetic modifications are known to constitute an important regulatory layer of transcription and DNA methylation is a major epigenetic modification that governs chromatid structure and gene expression.

In bacteria, which do not have histones, DNA adenine and cytosine methylation is the major epigenetic modification that influences the transcription of genes and that also protects DNA from cleavage by bacterial restriction-modification systems (which attack foreign DNA 3.

We investigated the expression levels of OsFIE2 and OsMET1b, two major epigenetic modification genes showing function seed development (Luo et al. 2009; Yamauchi et al. 2009; Nallamilli et al. 2013; Hu et al. 2014; Li et al. 2014) in the endosperm derived from the interploidy crosses and the parents Nip2n, TH4n and H2n (Fig. 3).

Symmetrical methylation of DNA at position 5 of cytosine within a CpG dinucleotide is a major epigenetic modification (∼5% of the total cytosine in the mammalian genome) although a small amount of 5-hydroxymethylcytosine (5hmC) generated from 5-meC by a methylcytosine dioxygenase has recently been detected in certain cell types [1] [3].

DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes.

DNA methylation is the major epigenetic modification that involves alterations of chromatin structure.

The methylation of cytosine within DNA is one of the major epigenetic modifications of the genome.

This article reviews the basic principles of major epigenetic modifications and discusses the epigenetic effects of major classes of human health-related environmental factors, including heavy metals, endocrine disruptors, polycyclic aromatic hydrocarbons, air pollution, and cigarette smoking.

Major epigenetic modifications include DNA methylation, histone acetylation and methylation which are often closely coupled [17].

Methylation is one of the major epigenetic modifications that repress transcription in vivo.

Numerous reports have described the major epigenetic modifications associated with the differentiation of ESC, but very little is known about the epigenetic regulators that interpret these chromatin marks and control the switch from the pluripotent state to the differentiation programs.