Sentence examples for major epigenetic changes from inspiring English sources

Genomic global hypomethylation, gene promoter region hypermethylation, histone modifications, and alteration of miRNA patterns are major epigenetic changes in colorectal cancer.

Major epigenetic changes during mitosis of somatic cells could be catastrophic for the organism, and we did not expect dramatic modifications.

Taken together, these studies suggest that the major epigenetic changes that occur during T cell polarization take place downstream of TCR ligation and cytokine signalling before the lineage-specifying factors are induced.

PGC specification commences at embryonic day (E) 6.25 from postimplantation epiblast; these epiblast cells undergo major epigenetic changes after implantation, including DNA methylation and X inactivation (Hayashi and Surani, 2009a).

The concept that during embryo development the major epigenetic changes affecting genome regulation represents the conversion from a euchromatic to a heterochromatic compact state (Arney and Fisher, 2004) has been amply debated (Golob et al., 2008; Marks et al., 2012).

Bomsztyk and colleagues have detected major epigenetic changes occurring in several organs as early as 6 h after the onset of a mouse model of multiple organ dysfunction syndrome induced by Staphylococcus aureus lung injury.

Silencing of tumour suppressor genes by hypermethylation is a major epigenetic change that contributes to tumour progression.

Epigenetic modifications are known to constitute an important regulatory layer of transcription and DNA methylation is a major epigenetic modification that governs chromatid structure and gene expression.

Histone proteins are the second major target of epigenetic changes.

Although no transposition burst was detected in S. anglica, major structural and epigenetic changes in the vicinity of TE insertions were observed, supporting a central role for TEs in genome reorganization during allopolyploid speciation (Parisod et al. 2009).

Here, we describe the producing of an allopolyploid from the cross C. morifolium × L. paludosum using ovule rescue and detail some of the major genetic and epigenetic changes induced by this intergeneric hybridization and polyploidization using a variety of DNA-based marker technologies.