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Slum conditions contributed to major epidemics from the 1760s through the 1800s.
Most major epidemics of typhoid fever have been caused by the pollution of public water supplies.
In addition, since the early 20th century, H1N1 has caused several major epidemics and pandemics.
Most major epidemics that have been controlled — from polio to measles — have been as a result of vaccines.
But India has had four major epidemics since 1994 last yearr alone 2.85m Indians got the disease and thousands died.
But they insisted that the lower-price drugs should be available only for major epidemics in poor countries and not for a wide variety of ailments.
Major epidemics began to occur in Europe in the 1880s, spreading later to the US and the rest of the world, sparking a race to develop a vaccine.
Rubella occurred worldwide before immunization programs were instituted, with minor epidemics arising every 6 to 9 years and major epidemics every 30 years.
Contaminated drinking water can induce major epidemics, disrupt economic life and create mass panics.
In parts of South America, for example, major epidemics occurred every 5 years in the early 1900s.
If the World Health Organization (WHO) is to better protect humanity from major epidemics, it will have to change fundamentally.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com