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AMPK is a major enzyme that regulates glucose and lipid metabolism in tissues including liver, adipose, and muscle.
The major enzyme that initiates the cleavage of hydrocarbon rings is laccase, which catalyzes the addition of a hydroxyl group to phenolic compounds (polyphenols).
The most abundant mammalian selenoprotein is glutathione peroxidase 1 (GPx1), which is a major enzyme that reduces H2O2 to water in the cytosol and uses GSH as electron donor.
Matrix metalloproteinase (MMP) 13 is a major enzyme that targets cartilage for degradation.
This result indicates that alpha-amylase is a major enzyme that hydrolyzes starch for glucose provision.
Beta-amylase is a major enzyme that hydrolyzes starch for glucose provision during late germination.
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Glutathione peroxidase and superoxide dismutase are 2 major enzymes that are involved in antioxidative defense mechanisms.
All major enzymes that are involved in the metabolism of xenobiotics are present in the skin.
Quinone oxidoreducatase is one of the major enzymes that convert 4-NQO to the more active metabolite, 3-hydroxyaminoquinoline 1-oxide [ 52].
Manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPX) 1 are two major enzymes that are responsible for ROS detoxification in mitochondria [ 7, 8].
We speculated that administering lithium acutely at 2 h before induction of MCAO would be sufficient to inhibit the major enzymes that are regarded as therapeutic targets of the drug (e.g., inositol monophosphatase and glycogen synthase kinase-3).
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Justyna Jupowicz-Kozak
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