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Glucose is a major energy substrate for polymorphonuclears (PMNs) and monocytes (Monos).
Glucose serves as the major energy substrate for articular chondrocytes and as the main precursor for the synthesis of ECM glycosaminoglycans in cartilage [ 35, 36].
Interestingly, CM metabolism is developmentally dynamic in that the fetal heart primarily utilizes glucose as its major energy substrate, and during postnatal maturation, the heart switches to primarily utilizing fatty acid oxidation (FAO) to meet its energy demands (Breckenridge et al., 2013; Lopaschuk and Jaswal, 2010).
For example, butyrate (which has prodifferentiation, antiproliferation and antiangiogenic effects on colonocytes [ 79]) is utilized by those cells as a major energy substrate; acetate is mainly metabolized in human muscle, kidney, heart and brain; and propionate is cleared by the liver [ 80].
Lactate was found to be the major energy substrate in the animals exposed to HA, especially during the acute acclimatization [ 1, 2, 5, 6], suggesting that anaerobic metabolism plays a major role in the energy production under the acute HA condition.
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Under non-ketotic conditions, the fetal myocardium has been shown to prefer fatty acids, glucose and lactate over ketones as its major energy substrates [ 34, 35].
However, this was a proof-of-concept study and endotoxemia is a valid model for demonstrating that myocardial concentrations of major energy substrates are affected by major inflammatory insults.
First, glucose is the only major aerobic and anaerobic energy substrate in the brain.
SjIR-1 and SmIR-1 [26] occur in the same location in the schistosome tegument as those of the schistosome glucose transporters SGTP1 and SGTP4 [57] which are involved in the considerable uptake of host glucose, one of the major nutrients and energy substrates for schistosomes.
Apart from being a major energy source in times of nutrient deprivation, adipose tissue-derived fatty acids serve as substrate for ketogenesis, the synthesis of ketone bodies (mainly β-hydroxybutyrate and acetoacetate) in the liver.
In early development, fats are the major energy source.
More suggestions(15)
principal energy substrate
major energy resource
major energy expenditure
major energy decision
major mTOR substrate
major energy penalty
major energy tax
major protein substrate
major energy source
major fuel substrate
major carbon substrate
major energy deal
major energy consumer
major energy shortage
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