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Central venous oxygen saturation (ScvO2) was used as the major endpoint of resuscitation in the intervention arm of the River' EGDT study (CVP > 8 cmH2O was targeted in both the control and intervention groups) and is a Grade 2C recommendation in the Surviving Sepsis Campaign Guidelines [5, 6].
Elapsed time from the start of bupivacaine infusion to cardiac arrest was defined as the major endpoint of the study.
The major endpoint of the study is the change in albumin excretion; secondary endpoints include markers of CVD, renal function, retinopathy, quality of life combined with assessment of compliance and potential health economic benefits.
47 The major endpoint of the study was overall survival and the time to PSA > 1.0 ng/mL and an increase in the PSA by >0.2 ng/mL on two consecutive occasions.
Central venous oxygen saturation (ScvO2) was used as the major endpoint of resuscitation in the intervention arm of the River' EGDT study (CVP > 8 cmH2O was targeted in both the control and intervention groups) and is a Grade 2C recommendation in the Surviving Sepsis Campaign Guidelines [ 5, 6].
The method is not intended to allow the calculation of a precise LD50, but does allow for the determination of defined exposure ranges where lethality is expected since death or appearance of toxic signs of a proportion of the animals is still the major endpoint of this test.
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The major endpoints of the DDR response, cell cycle arrest and apoptosis are not reached during the response to 32Hc.
One of the major endpoints of the CKD-ROUTE study is initiation of dialysis.
The data for the major endpoints of the study are summarized here.
All major endpoints of the study will be compared between the intervention and the control group.
One of the major endpoints of interest in management is to improve the quality of life, to preserve organ function without compromising survival.
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