Sentence examples for major effector pathways from inspiring English sources
In line with the observations mentioned above (Fig. 3), these analyses confirmed that the enhanced myeloid differentiation, in companion of the suppressed LSC program but not the enhanced apoptosis and cell cycle arrest, represented the major effector pathways of JMJD3 overexpression in AML cells.
In this review, we discuss these major effector pathways, focusing on their role in the pathogenesis of allograft rejection.
The ability of immunoglobulin and immune complexes, including autoantibodies, to provoke inflammation stems from the interaction of the Fc portion of antibody molecules with one or both of two major effector pathways: Fc receptors and the complement system.
Amongst these, three major effector pathways have emerged as being critical to mutant KRAS-mediated transformation and will be discussed in greater detail: the RAF-MEK-ERK pathway, the phosphatidylinositol 3-kinase (PI3K) pathway, and the Ral-NF-kB pathway.
The nuclear factor (NF -kappaB traNF -kappaBal systranscriptionaleffector pathway involved in inflammation and innate immune resystems.
While PI3K/AKT has been recognized as a major effector pathway of RRAS, only a minor impact on MAPK signalling had been reported (41, 42).
These results demonstrate that donor T-cells lacking major cytotoxic effector pathways have functions that support initial donor progenitor cell presence in the host hematopoietic compartment after BMT.
This can be achieved by dual targeting of either MEK1/2 and PI3K or MEK1/2 and mTOR for inhibition of the two major Ras effector pathways.
NF- κB pathway is a major downstream effector pathway leading to chemoresistance.
JAK-STAT signaling is a major cytokine effector pathway critical for the development and function of different immune cell types [ 1, 2].
The striking similarities of these mutant cerebellar phenotypes strongly argues that Foxc1-dependent SDF1α secretion by the posterior fossa head mesenchyme and its reception by Cxcr4 in adjacent early cerebellar anlage radial glial cells, represent a major downstream effector pathway mediating Foxc1 Dandy-Walker cerebellar pathogenesis 10.7554/eLife.03962.010 Figure 6.
