Results from our study identify HK2 as a major effector of PHLPP-mediated regulation of glycolysis.
We show that STAT5, a major effector of aberrant FLT3-ITD signal transduction, is both necessary and sufficient for this cooperative effect.
Angiotensin II (AII), the major effector of the renin-angiotensin system, is an octapeptide hormone for which no clear structural models exist.
By comparing noxE- and fdh-harbouring strains, the form of NADH, rather than NAD+, was the major effector of furfural tolerance.
Vascular endothelial growth factor C (VEGF-C), the major effector of lymphangiogenesis, is indispensable for lymphatic development in mouse embryos and essential for most lymphangiogenic processes in adults1,2,3.
mAb-131 is a monoclonal antibody that binds with high affinity (K alpha = 7.4 x 10 9) M-1) to the 8-residue peptide hormone angiotensin II, the major effector of the renin/angiotensin system.
Ex vivo stimulation of peritoneal macrophages with LPS elicited proinflammatory responses that were dependent on EP2 signaling and that overlapped with in vivo plasma findings, suggesting that myeloid-lineage EP2 signaling is a major effector of innate immune responses.
The AM, a major effector of early resistance to bacterial infection, can be affected by ventilation [16].
A major effector of neutrophils with a critical role in CF is neutrophil elastase (NE), a serine protease composed of 218 amino acids.
Upon tissue injury, the activity of YAP, the major effector of the Hippo pathway, is transiently induced, which in turn promotes expansion of tissue-resident progenitors and facilitates tissue regeneration.
The complement system is the major effector of the humoral arm of the immune system.
