Sentence examples for major effector molecules from inspiring English sources
ROS are major effector molecules in inflammatory processes and tightly linked to NETs formation.
Akt is one of the major effector molecules following PI-3K activation.
Proinflammatory cytokines and chemokines are considered to be the key regulators, and certain proteases to be the major effector molecules, in the pathomechanism of the disease.
Matrix metalloproteinases (MMP's) are important in extracellular matrix remodeling, are major effector molecules of inflammatory cells, and play a key role in many vascular diseases, including hypertension and aneurysm formation [ 7, 8].
With a well designed experiment, it is now possible to use gene expression to identify causal mutations and the other major effector molecules with whom they cooperate, irrespective of whether they themselves are DE.
In this correspondence piece we describe a previously published set of gene expression analyses [ 1- 4] - developed on skeletal muscle, but universally applicable – that can correctly determine the site of causal mutations and prioritise major effector molecules, in the absence of Differential Expression (DE).
Regarding the mechanism of action of MLR suppression, transwell experiments revealed that in neither UCMSC culture a direct cell cell contact is necessary for inhibiting T cell proliferation, and that the major effector molecule is prostaglandin E2 (PGE2).
A major effector molecule of inflammatory MØ is NO, which is synthesized by inducible NO synthase (iNOS) from L-arginine (L-Arg).
Angiotensin II is the major effector molecule of the renin-angiotensin-aldosterone system (RAAS) and plays a key role in the regulation of blood pressure (BP) by increasing vascular tone and promoting sodium retention.
EGFR stimulates proliferation and migration of epithelial cells and is generally considered to be the major effector molecule in corneal wound healing [ 16].
Granzyme B is a major effector molecule of granule-mediated killing that rapidly induces cell death after entering the cytoplasm of the target cell [ 17].
