Sentence examples for major effector molecule from inspiring English sources
Regarding the mechanism of action of MLR suppression, transwell experiments revealed that in neither UCMSC culture a direct cell cell contact is necessary for inhibiting T cell proliferation, and that the major effector molecule is prostaglandin E2 (PGE2).
A major effector molecule of inflammatory MØ is NO, which is synthesized by inducible NO synthase (iNOS) from L-arginine (L-Arg).
Angiotensin II is the major effector molecule of the renin-angiotensin-aldosterone system (RAAS) and plays a key role in the regulation of blood pressure (BP) by increasing vascular tone and promoting sodium retention.
Granzyme B is a major effector molecule of granule-mediated killing that rapidly induces cell death after entering the cytoplasm of the target cell [ 17].
EGFR stimulates proliferation and migration of epithelial cells and is generally considered to be the major effector molecule in corneal wound healing [ 16].
Second, macrophage activity may alter over time as a consequence of tumour-induced immune dysfunction, since nitric oxide production, which is a major effector molecule for tumour cell killing, was suppressed in macrophages of tumour-bearing mice [ 32].
ROS are major effector molecules in inflammatory processes and tightly linked to NETs formation.
Akt is one of the major effector molecules following PI-3K activation.
Proinflammatory cytokines and chemokines are considered to be the key regulators, and certain proteases to be the major effector molecules, in the pathomechanism of the disease.
With a well designed experiment, it is now possible to use gene expression to identify causal mutations and the other major effector molecules with whom they cooperate, irrespective of whether they themselves are DE.
Matrix metalloproteinases (MMP's) are important in extracellular matrix remodeling, are major effector molecules of inflammatory cells, and play a key role in many vascular diseases, including hypertension and aneurysm formation [ 7, 8].
