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These data suggest that the fetal fibroblast is the major effector cell for scarless fetal skin repair.
These data identify the Type A macrophage-like synovial lining cell as the primary source of collagenase mRNA in vivo in the rheumatoid arthritis synovium and, potentially, as a major effector cell in the tissue destruction of the disease.
As IgE/antigen immune complexes (IgE-IC) bind to human cells through FcεRI or FcεRII/CD23 surface molecules, the present study aimed to identify which functional receptor may be involved in IgE-IC interaction with human macrophages, the major effector cell during parasite infection.
FLS are considered a major effector cell type involved in cartilage erosion, based on their ability to produce massive amounts of degradative enzymes, such as MMPs.
In this way, type I and II IFNs exert a pronounced and clinically important effect upon macrophages, a major effector cell of the innate immune system.
This might be of significance in light of the recent exciting finding that IL-1-induced granulocyte-macrophage colony-stimulating factor is important for the pathogenicity of Th17, a major effector cell driving inflammation and autoimmunity [ 8].
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CD8+ T cells were a major effector cell-type of antitumor response in the immunized mice with the Fb/B7.1/IL7/OVA cells.
The immunological basis of tumor response is based on tumor-specific CD4+ T helper type 1 (Th1) in the priming phase and tumor-specific CD8+ T cells as the major effector cells.
As discussed above, neutrophils are the major effector cells that lead to early graft loss in islet transplantation.
The mast cell is one of the major effector cells in inflammatory reactions and can be found in most tissues throughout the body [1].
Macrophages and lymphocytes are generally considered the major effector cells controlling the disease in vivo [7], [8] through TNF-α and IFN-γ production [9], [10].
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