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The major effect observed was advancing the time cells entered MI (MI was initiated at the same time cells initiated DNA replication, Figure 6C).
All the three agents resulted to be active in inhibiting cell proliferation, with a major effect observed after everolimus treatment.
The global reduction in ischaemic events and mortality was driven by the major effect observed in the setting of primary percutaneous coronary intervention for ST elevation myocardial infarction and is in line with the results of the ATOLL randomised trial.
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Comparisons between the present data trends and those reported for jet-by-jet shielding suggest that the major effects observed in the latter are acoustical rather than aerodynamical.
Significant reduction in drop size and increase in acceleration with increasing field strength are the major effects observed, while alteration in drop shape and oscillation are slight.
The major effects observed when considering kinetics in the calculations are to smooth the sharpness and intensity of the mineralogical transformation fronts, these fronts being predicted to occur deeper inside the argillite matrix (<1 cm) and the fractures (⩽2 cm), as well as to lessen clogging of pores within the argillite.
Treatments of mouse embryos between 7 and 8 dpc are known to result in severe axial defects including vertebral and CNS transformations [70], [71] with no major effects observed on craniofacial structures.
With the recently legislated "breakthrough product" definition in the U.S., it may be possible to plan a single trial for registration purposes to confirm a major clinical effect observed in phase I.
The major effect is observed for the fuel-lean and stoichiometric mixtures.
No major effect was observed in STAT3 phosphorylation levels using Akt or ERK inhibitors.
After enzymatic treatment the tissue appears slightly disorganised, but no major effect is observed.
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CEO of Professional Science Editing for Scientists @ prosciediting.com