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The major drawback to Botox, experts say, is cost.
The major drawback to prefabrication is the dilution of responsibility.
The major drawback to selecting Mr. Edwards is his relative inexperience.
There is, of course, one major drawback to putting men in corsets, even in Shakespeare.
There's one major drawback to most proposed renewable-energy sources: their variability.
There is one major drawback to using Wi-Fi to connect a player and speaker.
The major drawback to using this approach is the relatively large volumes and high concentrations necessary.
The inherent brittleness of continuous unidirectional fibre reinforced composites is a major drawback to their otherwise outstanding mechanical performance.
However, the climate-induced performance degradation represents a major drawback to solar making them unreliable for unattended or remote plants.
The major drawback to this plastic is its relatively low strength as compared to other engineering plastics.
That brings up a major drawback to ads that borrow interest: They tend to proliferate to the point they seem derivative and unoriginal.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com