Sentence examples for major downstream target from inspiring English sources

Similarly, cultures from Scl-/ EB cells showed more cells positive for COLLAGEN IIA, major downstream target of Sox934, and increased ColIIa mRNA expression (Fig. 3f).

We further demonstrated that CCAAT/enhancer-binding protein (C/EBP) δ transcription factor was the major downstream target of SOCS3 in macrophages.

AMPK is a master regulator of energy homeostasis in the cell; it is activated in response to a decrease in ATP/AMP ratios and is a major downstream target of the most prescribed drug for patients with type 2 diabetes, metformin69.

However, whether TAZ serves as a major downstream target of miR-9-3p whinhibitsbits HCC cell proliferation remains elusive (Higashi et al., 2015).

mTOR is the major downstream target of Akt and the inhibition of PI3 K-Akt-mTOR signaling pathway plays important roles to activate autophagy (Pattingre et al. 2008; Zhang et al. 2016; Pang et al. 2016).

XBP-1 splicing is a major downstream target of the IRE1 signaling.

Type 2A phosphatase (PP2A) and PP2A-like phosphatase (Sit4) are identified as major downstream targets of the TORC1 pathway[10] [10].

Since Akt is one of the major downstream targets of PI3K signaling, its phosphorylation status is commonly used to monitor the activity of the PI3K/Akt pathway.

In order to clarify that the myosin activity on cell adhesion is under the Rock regulation at the functional level, we focused on myosin phosphatase target subunit 1 (MYPT1), one of the major downstream targets of Rock that negatively regulates myosin function through dephosphorylation of myosin regulatory light chain (MRLC) [35].

Among other cell cycle factors, mice lacking the Rb-related pocket proteins p107 and p130 show skeletal phenotype very similar to that of the p57−/− mice [48], indicating that these proteins are likely to be major downstream targets of the cyclin-CDK complexes that are inhibited by p57 in chondrocytes.

Major downstream targets of mTOR signaling are components of the translation machinery [ 58].