Sentence examples for major downstream substrate from inspiring English sources

A major downstream substrate of AKT is the serine/threonine kinase mTOR.

To determine the major downstream substrate that FBW7 might target in PDAC, we next examined changes in the known substrates responding to FBW7 overexpression by western blot.

47, 99, 100 FoxO1 activates the transcription of the eukaryotic initiation factor 4 binding protein-1 (4EBP-1), which is a major downstream substrate of mTORC1 and functions as a potent translational inhibitor and growth suppressor.

PDK1 is a crucial component of cell growth and survival signalling pathways that also involve its upstream regulator PI3K (phosphatitylinositol-3-kinase), its major downstream substrate Akt/PKB (protein kinase B) and the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10), which acts as a negative regulator of PI3K/PDK1/Akt signalling.

The major downstream substrates of ROCK include the myosin binding subunit of myosin light chain (MLC) phosphatase 1 (myosin, myosin light chain 2 (MLIM), LIM kinases, thereby modulating actin cytoskeleton organization, stress fiber formation and smooth muscle cell contraction.

Recent studies have also shown that Ras-related C3 botulinum toxin substrate 1 (Racombinedbined with its major downstream effector p21-activated kinase 1 (PAK1), hastened EMT formation of podocytes via HG stimulation by promoting β-catenin and Snail transcriptional activities, which may be a potential mechanism in podocyte injury under diabetic conditions [ 40].

Even in the absence of exogenous growth factors, mTOR activity remained remarkably elevated in glucose-fed cells 24 hours after serum withdrawal, as revealed by the phosphorylation patterns of the major mTOR effectors S6 kinase and 4E-BP1, and of the downstream substrate S6.

Although the major downstream target of LKB1 tumour suppressor is AMPK, LKB1 has at least 12 other substrates, which include members of the AMPK-related protein kinase subfamily, such as MARK1-4 (Lizcano et al, 2004).

This compound (1 μM) inhibited the phosphorylation of its downstream substrate, ribosomal protein S6 (Fig. 5d), but had no effect on TGF-β1-induced collagen synthesis (Fig. 5e).

ADP-ribosyltransferases (ARTD1 16) have emerged as major downstream effectors of NAD+ signaling in the cell.

Aramco began this process in the 1990s, building off of its domestic downstream and its Motiva investment, by participating in major downstream operations across Asia.