Sentence examples for major downstream signalling from inspiring English sources
This choice was not arbitrary, as this pathway is one of the major downstream signalling pathways from EGFR.
The PI3K pathway is a major downstream signalling pathway utilised by the most important growth/survival factors for MM.
A recent study showed that CBF1, the first major downstream signalling factor of the Notch pathway, when activated, interacts with the Cyclin Dl promotor, resulting in increased CD1 activity and Gl/S-phase transition (Ronchini and Capobianco, 2001).
The RAS RAF MAPK kinase is the major downstream signalling route of the EGFR pathway and it controls cell-cycle progression, differentiation, survival and in particular, the G1/S-phase transition (Ciardiello and Tortora, 2008).
The two major downstream signalling pathways in vertebrates and invertebrates are the ERK1/2 mitogen-activated protein kinase (MAPK) cascade and the phosphoinositide-3-kinase (PI3K /protein kinase B (PKB; also known as Akt) pathway [ 7- 9].
A major downstream signalling route is via the Ras-Raf-MAPK.
A major downstream signaling effector of cAMP is protein kinase A (PKA) and the cAMP-PKA signaling pathway has been shown to regulate MKP-1 expression32,33.
We next treated cells by 8-Br-cAMP and Sp-DCl-cBIMPS, activating two major downstream signaling ways of cAMP, i.e., protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac), as well as by 6-Bnz-cAMP (thought to act as a rather selective PKA activator 28 or by 8-pCPT-2′-O-Me-cAMP (activating only Epac 29.
The major downstream signaling pathway of IL-6 is JAK-STAT, and STAT3 activation primarily occurs in neurons during ischemic reperfusion (Suzuki et al., 2009).
These data point to CaMKII as a major downstream signaling molecule that is activated by OAMB in the oviduct epithelium for ovulation.
The effect of NGF stimulation on the second major downstream signaling pathway regulated by phosphorylation of Akt was also analyzed in PC12 cells transiently expressing the Rab7 Cmutantstants.
