Sentence examples for major downstream pathway from inspiring English sources

As a comparison, we are also analyzing another major downstream pathway of Ras, Mek-Erk1/2, which acts downstream of Raf [18].

This might suggest that JAK signalling is not a major downstream pathway in these cells.

Consistent with MAP kinase signaling being a major downstream pathway activated by TNFα, we found that a chemical inhibitor of JNK but not p38 could partially antagonize NKX3.1-induced expression of HSPA6 and HES1.

These results demonstrated that HER2/HER3 signaling and its major downstream pathway, PI3K/Akt signaling, but not ATM/ATR signaling, are involved in the VPA-induced upregulation of MICA and MICB in pancreatic cancer cells.

Downregulation of components of the MAPK pathway, a major downstream pathway of FGFR1, was also observed, such as p-MEK1, c-Fos, and p-c-Fos (Additional file 2: Figure S1C).

Subsequently, to determine the involvements of the downstream effectors of Ras in these two processes, we analyzed the two major downstream pathways, PI3 Kinase pathway and MAP Kinase pathway respectively.

MDCK-Ras cells display strong activation of PI3K and ERK1/2 signaling, two major downstream pathways of Ras [ 67].

We have determined that upon IGF-1 ligand stimulation, IGF-1R conveys its signal via the MAPK/ERK and PI3K/Akt pathways, the major downstream pathways integrating signals from RTKs, to mediate antiestrogen resistance in MCF7/IGF-1R cells.

ERK1/2 mitogen-activated protein kinase (MAPK) and AKT are signaling molecules on major downstream pathways initiated by the activation of EGFR and related with cell proliferation (Lim and Cha 2011; Kim and Lim 2011).

Besides the KRAS BRAF pathway, the other major downstream signaling pathway activated by EGFR is the PI3K AKT signaling pathway.

NF- κB pathway is a major downstream effector pathway leading to chemoresistance.