Sentence examples for major downstream mediator from inspiring English sources

Stat5 was identified as a major downstream mediator of TEL SYK in vitro as well as in vivo.

PUMA, a proapoptotic protein, was identified as a major downstream mediator of the apoptotic actions of p53.

It is not surprising that anti-TNF treatment blocks the pathology, but it is a remarkable observation that IL-1 is a major downstream mediator.

Mechanistically, Zic2 is thought to act in part via the regulation of β-catenin activity, which is a major downstream mediator of Wnt signaling (Pourebrahim et al. 2011).

It has been suggested that dSmad2, the major downstream mediator of TGFβ signals, might participate directly in regulating Halloween gene transcription.

To see whether myofibers are susceptible to IFN-γ, we analyzed the expression of both chains of IFNGR and its major downstream mediator STAT1 in AIBM versus NIBM and HCTRL myofibers with TaqMan qPCR.

Using Western blot analysis, ELISA and real-time RT PCR analysis, we have demonstrated that TGF-β1 stimulated IL-6 expression and activated major downstream mediators, including phospho-Akt and phospho-STAT3.

To decipher the molecular basis for how targeting IL13Rα2 suppressed breast cancer metastasis, we examined the phosphorylation status of STAT proteins and found enhanced STAT6 phosphorylation as the major downstream signaling mediator.

A major challenge will be to distinguish the ambivalent functions of RSK2 both as a downstream mediator but also as a negative regulator of MAPK signaling in these processes, and to explore potential differential effects on local MAPK signaling.

Connective tissue growth factor (CTGF) is a downstream mediator of TGF-beta activity that is associated with scar and fibrosis.

It probably suggests that NF-kB is a downstream mediator of the GSK-3 signaling cascade.