Sentence examples for major downstream effect from inspiring English sources
"We've only just begun on the naked mole rat story, and already a whole universe is opening up that could have a major downstream effect on human health.
In conclusion, this study provides the biochemical and molecular underpinning for direct targeting of AMPK in PCa therapy, with the downregulation of lipogenesis representing the major downstream effect of this therapeutic approach.
Such transition is bound to have major downstream effects on the bacterial virulence gene expression [38], [39], [40].
Finally, hypoxia in airway epithelium is known to result in many major downstream effects mediated through HIF1-α, and Mo et al. offers the first investigation into the potential roles of HIF1-α in allergic rhinitis.
One of the major downstream effects of receptor activator of nuclear factor kappa-B ligand (RANKL -induced activation of Ca2+ signaling is nucleaRANKL -inducedn of dephosphorylactivationar factof of aCa2+ated T cellsignalingasmis 1 (nuclear (translocation007), and, cofsistent with this, there was redephosphorylated of nuclearin Kcnn4−/− osteoclasts.
SERPINB5 produces a protein also known as maspin, and is thought to be a major downstream effector for the tumor suppression effect of Tamoxifen [ 66- 68]; therefore, it is possible that CCM+DHA modulates a pathway overlapping that of Tamoxifen.
Notably, Pitx2, an immediate early transcription factor target whose expression is solely dependent on Smad2/3 activation in ES cells, is expected to be involved in major downstream transcriptional effects.
ROCK is a major downstream effector of RhoA GTPase.
11 A major downstream effector of AKT is mTOR complex1 (mTORC1); its downstream targets, such as ribosomal S6K1, control protein synthesis.
CREB is one of the major downstream effectors of neurotrophins and has similar antidepressant effects to BDNF when expressed in the hippocampus.
Therefore, we measured EGFR and its major downstream targets in tumours to demonstrate drug-mediated effects on critical cell signalling pathways from treated mice.
