Sentence examples for major downside however from inspiring English sources

The major downside however, is that eType currently only supports Windows XP and above.

There was one major downside to Australia's day however, as Will Genia - standing in as captain with James Horwill and David Pocock already ruled out of the championship - was forced off with a knee injury 10 minutes from time.

However, the major downside is that the cell's enzymes prefer the natural substrate over the non-canonical ones, resulting in relatively low levels of tagging.

However, the insertional mutagenesis associated with these vectors still represents a major downside of this type of approach.

However, he added that the EU referendum on 23 June posed a "potential major downside risk to housing market activity and prices".

There is a downside, however.

There's a downside, however: guilt.

The downside, however, is the cumulative cost.

Major downside: limited experience with his team in European competitions.

"Clearly there is a major downside risk to U.S. growth.

"However, such factors as the weakening momentum of economic recovery in the U.S. and other major countries and the spread of sovereign debt problems in the euro area will act as major downside risk factors".