The phrase "major divergence" is correct and can be used in written English.
You could use it to describe a situation in which two similar paths, theories, or ideas take very different courses. For example, "The company split in two, creating a major divergence in their operational strategies."
The estimated gene numbers indicate that OR genes diverged gradually, with the major divergence occurring during early mammalian evolution, between the mammal-bird split and the placental-marsupial split.
The pathogens responsible were not isolated and characterised in the majority of patients and thus represent the major divergence between current practice in the Gulf region and the IDSA/ATS guidelines.
Since mid-March, there has been a major divergence in the market, with growth stocks — shares of companies whose earnings are growing faster than the market as a whole — posting positive returns, and dividend-paying value stocks falling.
But it represents the first major divergence from traditional connectivity in this century.
Overall, it was found that there was no major divergence between approaches or criteria used for capacity evaluation in the U.S. and Europe.
Molecular dating analyses suggest the major divergence between eastern mesic and monsoonal species occurred in the Miocene approximately 17 million years ago, with repeated evolution of species from monsoonal biomes to arid or mesic biomes in the later Miocene, early Pliocene and at the beginning of the Pleistocene.
Game of Thrones began taking major divergences from A Song of Ice and Fire in its second season and is now a materially different story.
The two major divergences in The First Book of Samuel lie in those passages that critics call the "pro-monarchic" source (1 Samuel 9 1 10 16) and those passages called the "antimonarchic" source (1 Samuel 8 and 10 17 27).
While intensifying as a tropical storm, the National Hurricane Center faced difficulties in the future track of Jeanne, based on two major divergences between computer hurricane models.
Keyes added that, despite Cyrus' charisma, it was evident the show and the dual-persona arrangement (considering that there were no major divergences between them) was an evident strategy to extend marketing and receive more profits.
American football resulted from several major divergences from rugby, most notably the rule changes instituted by Walter Camp, a Yale and Hopkins School graduate considered to be the "Father of American Football".
