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Based on these findings, trastuzumab is now considered a key drug for treating HER2-positive breast cancer, which has been established as a major disease subtype of breast cancer.
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The group learned to appreciate three major disease subtypes.
A large number of genetic susceptibility loci have been uncovered in relation to IBD, with pervasive sharing of genetic susceptibility loci between the two major disease subtypes, UC and CD [ 4].
One major difficulty of disease subtype discovery using multi-omics data is the possible heterogeneity of clustering results from different omics data.
Bovine tuberculosis is a really major disease.
Here we have employed quantitative, image registration-based DTI methods to demonstrate profiles of white matter tract damage in a large cohort of patients with bvFTD, representing the major genetic and sporadic disease subtypes.
For instance in the city of Sao Paulo, the major subtypes are subtype B (79%–88%) and subtype F (4%–11%) [4], [5].
For MS, unraveling the pathogenetic events behind the disease subtypes represents a major goal for understanding and generating the most appropriate and efficacious treatment for that disease phenotype.
This problem arises from various technical and biological sources including platform differences [2], and has been a major obstacle to moving microarrays into the clinic as a tool to uncover as yet unrecognized disease subtypes.
"Where do the major diseases come from?
Chronic kidney disease (CKD) is often clinically silent and traditional clinical data alone cannot differentiate disease subtypes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com