"major disability" is correct and usable in written English.
For example: She had suffered a major disability since birth.
Many patients with these pathogenic mtDNA mutations present with a progressive, disabling neurological syndrome that leads to major disability and premature death.
The decision to undertake resuscitation at birth enables long-term survival without serious sequelae for the majority, but it may lead to the survival of children who sometimes have major disability.
Musculoskeletal diseases continue to produce major disability around the world.
Strokes can be mild or temporary, or so severe that major disability or death occurs.
Mr. Tate suffers from a major disability: a spinal malformation resulting from congenital spina bifida and kypho-scoliosis.
You can have a major disability and live well — people do it all the time, as these two girls demonstrate.
Then there are the students who don't declare a major disability, either through pride or because there isn't the right box on their Ucas form.
The Australian newspaper reported that the family applied for a major disability package, worth about $383,000, under Australia's National Disability Insurance Scheme in 2016.
Atherosclerotic cardiovascular disease (ASCVD) events, including coronary heart disease and stroke, are the most frequent cause of death and major disability in the world.
"That mom braved bumper-to-bumper traffic on Route 22 with her son, who has a major disability" — autism — "to get here," she said later.
On the cell phone, we called marinas to find one we could be towed to that would deal with a major disability and a powerless boat on a Saturday.
