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The major difficulty to biodiesel commercialization is its high cost, which is approximately 1.5 times higher than petroleum diesel fuel, due to the cost of vegetable oil.
The French prime minister, François Fillon, told members of the governing party this week that "we are stuck with a major difficulty — to convince Germany that we should arm the euro zone with an instrument of defense for our currency with a certain evolution of the role of the central bank".
The major difficulty to overcome, before confirmation becomes meaningful, is the generally inadequate data for establishing rigorous statistical tests.
It is a major difficulty to produce the 1 13 phase because of its low phase stability at elevated temperatures and low atomic diffusivity [11,12].
Still, lack of substantial fossil evidence of the development of the wing joints and muscles poses a major difficulty to the theory, as does the seemingly spontaneous development of articulation and venation, and it has been largely rejected by experts in the field.
One major difficulty to overcome is our lack of a detailed quantitative understanding of the innate immune response.
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Which are the major difficulties to be overcome?
This method can be extended without major difficulties to higher dimensional cases.
Using data mining methods, this paper presents a new means of identifying freshmen's profiles likely to face major difficulties to complete their first academic year.
Moreover, the fact that large areas (or even whole brain) could be irradiated without significant side effects, could allow overcoming one of the major difficulties to be faced in gliomas treatment: its infiltrative nature.
Although it is logical that definitive evaluation of new therapies should be based on clinically meaningful outcomes, there are major difficulties to overcome when conducting treatment trials in multiple sclerosis (MS) with clinical endpoints such as relapse rate or progression in disability.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com