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The major difficulty stems from the network model which consists of highly nonlinear coupled equations.
A major difficulty stems from the fact that such an allocation must be established several months in advance, and the exact number of patients for each specialty is an uncertain parameter.
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The second major difficulty stemmed from the time reversibility of the kinetic theory.
A major difficulty in targeting cancer stem-cells is the absence of specificity of surface markers, and thus a major risk of adverse events from direct targeting of normal cells.
A major difficulty in protein phosphorylation prediction stems from the fact that each kinase has its own particular specificity determinants [11], [12].
Although the criterion in (11) is convex, a major difficulty that arises in solving this problem stems from the fact that the function to be minimized is not differentiable.
A major difficulty in understanding the biophysical and biochemical bases of fibroblast motility stems from the wide variety of motility these cells can display at a given time.
A major difficulty in achieving the desired change is that the teaching practices used in college and university STEM courses remain largely unmeasured.
Lighting is a major difficulty.
The accounting difficulty stems from the wide range of possibilities.
But there will be one major difficulty.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com