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The major difficulty addressed in this algorithm is the non independence of transmission events from the sire and the dam to the progeny in triple heterozygous trios.
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You say they had great difficulty addressing the connection between Communist ideology and systematic mass murder.
A single mother may have more difficulty addressing the issue.
Despite the success of existing algorithms, a major difficulty that has not been sufficiently addressed is that of predicting rare labels.
The major difficulty of the Poisson Neumann problem solvability is addressed and correctly treated.
It addresses major difficulties in designing embedded middleware, such as the narrow bandwidth of the communication medium and the limited size of the payload.
To address major difficulties and threats to childhood in Tajikistan, UNICEF advises, mobilizes and supports initiatives aimed at enhancing and advancing actions in the following areas, which are all reflected in the specific components of the current UNICEF programme cycle in Tajikistan (2010-2015).
All are major difficulties Americans deal with every day but none of it was deemed important enough for mention as a part of an address about the state of our union.
Lighting is a major difficulty.
But there will be one major difficulty.
In my view, the major difficulty we have today with Strindberg is his difficulty.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com