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There are many obstacles to obtaining structures of GPCRs by X-ray crystallography; the major difficulties include poor protein stability and absence of homogeneity during crystallization due to inherent properties of these receptors [ 6, 9, 10].
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However, these difficulties, including a major de-motivating event, appeared to have little effect on either the time taken or the effectiveness of the decisions reached.
Hearing difficulties included problems with the discrimination of the major music tones, tone structures falling apart, and problems with tuning out noisy surroundings when engaged in conversation.
Surveys from the physicians' perspective in other clinical settings (mainly oncology) also identified time constraints, including time required to obtain informed consent [ 16, 3] and difficulties including eligible patients [ 16] as a major barrier for patient recruitment.
Signs include: Breathing difficulties, including wheezing.
The major difficulties during the tunneling include [2]: (1) Geological prediction Water/mud bursts relate closely to geological conditions, especially the caves in rock; a precise prediction of the karst caves, therefore, becomes one of the main concerns in order to avoid water/mud bursts.
They have accomplished this in spite of a variety of problems since the Great Recession ended including major difficulties in managing cash flow, getting or renewing loans, and securing start-up capital.
In order to rule out any major difficulties with NW repetition, we included a NW repetition task in our pretest procedure.
Vaccine development against malaria is focusing largely on subunit technologies [9], where the major obstacles include difficulties to retain the native conformation of key antibody epitopes and the need for an effective but safe human-compatible exogenous adjuvant [10].
to this heterogeneity, one of the major difficulties of this review is generalising the evidence of included studies.
Almost all patients with major depression report some form of sleep difficulty including insomnia, oversleeping, and poor-quality sleep.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com