Sentence examples for major difficulties and from inspiring English sources

Obama is already set to inherit some major difficulties and does not need his incoming government to be hampered as a result of Bush's failure to fulfil his role during this transition period.

Compressed air alone was used to hold back the water in 1880 in a first attempt to tunnel under New York's Hudson River; major difficulties and the loss of 20 lives forced abandonment after only 1,600 feet had been excavated.

Other items included: "How did you function in your daily activities today?" (rated on a 0 3 scale: 0 = No difficulties, 1 = Minor difficulties, 2 = Medium difficulties, and 3 = Major difficulties); and "Did you take any acute medications to treat headache today?" (No/Yes).

Operation proved to give several major difficulties, and by March 2001, Oslo Sporveier was threatening to terminate the purchase agreement unless the manufacturer who by then had merged to become AnsaldoBreda fixed the problems.

Forward and back-translations of the SPADI revealed no major difficulties and consensus was reached on a preliminary Norwegian version.

We pilot tested the changes and patients were able to complete the German CRQ-SA without major difficulties and understood all items and answer choices.

The major difficulty and challenge for CART cells targeting CSCs is the development of on-target/off-tumor toxicity that is caused by CART cells killing normal cells, because CSC surface markers are also found on normal cells.

Both simple mutants were obtained without any major difficulty and were confirmed by Western Blot analysis (Figure 2A, lanes 1 3).

While the response rate was 94%%, overall satisfaction with QDU was high in 93 % of cases, repeated travel to hospital was not considered a major difficulty, and 84%% of patients would choose the QDU instead of hospitalization should a further diagnostic workup be required [ 21].

He was treated with dipiperone (60 mg in the evening) because of pronounced hyperactivity, increased aggression and major difficulties falling and staying asleep.

The reality creates problems and new and major difficulties in the design and implementation of training programs in schools, in the appropriate ways of teaching, of active teaching methods and strategies centred on problem solving, but the solution comes to life through the cross-curricular mechatronics, an engineering approach at the secondary level.