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Specific identification of Bacillus anthracis and differentiation from closely related Bacillus cereus and Bacillus thuringiensis strains is still a major diagnostic problem.
Thus, a high intra- and interlaboratory variability is common and represents a major diagnostic problem, especially in non-specialized laboratories [ 17, 18].
Differential diagnosis of carcinomatosis peritonealis or abdominal disseminated malignancy presents a major diagnostic problem and only biopsy and histological analysis can reveal the underlying disease.
The major diagnostic problem is the differential to other renal tumors: (i) the eosinophilic or granular variant of clear cell renal carcinoma (RCC) and (ii) the chromophobe RCC.
With the detection of an ACT, the major diagnostic problem is to exclude the possibility of malignancy in one or both of the components.
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The myriad symptoms of the syndrome also present major diagnostic problems for primary healthcare providers.
Low-back pain is a major diagnostic and therapeutic problem, which causes a great deal of suffering and is a major expense to society [ 1, 2].
However, major diagnostic and prognostic problems often arise by histopathological assessment (WHO classification) since seven types of endometrial carcinoma can be distinguished.
Thus, solving an uncertain diagnostic problem amounts to solving at one time several traditional diagnostic problems.
Tubercular uveitis poses a major diagnostic challenge in endemic countries.
Apnea and brain stem testing are the major diagnostic approach.
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