This finding was mainly due to proteins involved in major developmental processes and the visual cycle.
Here PCD governs two major developmental processes.
In fact the Hh pathway is one of the four major signaling systems that are controlling the major developmental processes.
This phase encompasses three major developmental processes: sexual reproduction (including gametogenesis and fertilization), meiotic development of the zygote/ookinete and vegetative growth of the oocyst via endomitotic replication.
This process, referred as CD4 and CD8 commitment, is a major developmental process after positive and negative selection.
For instance, it is well known that the major developmental process at 4 6 stages is differentiation, but there is no differentiation at 1 3 stages in the maternal region.
DOI: http://dx.doi.org/10.7554/eLife.01567.011 Secondary growth is a major developmental process in dicotyledons, including herbaceaous plants such as Arabidopsis (Chaffey et al., 2002; Sibout et al., 2008; Elo et al., 2009); however, it is comparatively an under-researched trait.
Given that thymic positive selection serves as a major developmental process to generate mature T cell repertoires (Jameson et al., 1995; Morris and Allen, 2012), one may reason positive selection would play a role in determining naive T cell precursor frequency to dictate immunodominance.
It is classically described to act upstream of and govern major developmental patterning processes (e.g. inter-digitations in vertebrates, ommatidia in Drosophila).
FETAX, which is used to evaluate interruption of critical cellular behaviors during embryogenesis, relies on a 96-hr exposure protocol beginning early in development through all major early developmental processes such as gastrulation, neurulation, and organogenesis (NF stages 8 46) and analyzes severe end points such as lethality [ American Society for Testing and Materials (ASTM) 1988].
It generates the need for tight control of cell rearrangement and changes in shape, imposing major constraints on developmental processes [3].
