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It is classically described to act upstream of and govern major developmental patterning processes (e.g. inter-digitations in vertebrates, ommatidia in Drosophila).
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For example, this dataset includes (i) SVs with different splicing patterns covering major developmental stages of developing soybean embryos, (ii) coding and noncoding transcripts such as lncRNAs and antisense transcripts, (iii) SVs with different number and types of conserved domains with the same and/or different expression profiles.
Resolution of apnea and establishment of a normal respiratory pattern is a major developmental milestone for many premature infants.
The history of selection in regions such as this one with major developmental genes often leaves complicated linkage disequilibrium patterns which add confusion to the interpretation of results.
Moreover, their relatively small cost permits to rapidly implement a prototype design without major developmental constraints.
Many of the motifs in footprints display highly cell type selective occupancy patterns that are similar to major developmental and tissue-specific regulators [12].
Major 'macro-evolutionary' changes in wing color patterns could thus be controlled by very few genes, or even one single major developmental gene [ 10, 11].
We hypothesized that more frequent sampling would reveal unappreciated patterns in gene expression, and provide a more precise understanding of the transcriptional dynamics that govern major developmental transitions.
Renner, M. et al. Self-organized developmental patterning and differentiation in cerebral organoids.
Hamant, O. et al. Developmental patterning by mechanical signals in Arabidopsis.
Thus, loss of nFGFR1 and excessive nFGFR1 signaling lead directly to dysregulation of major developmental pathways.
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