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The major determinants affecting the severity of the pyridoxine neuropathy appear to be duration and dose of pyridoxine administration, differential neuronal vulnerability, and species susceptibility.
The themes we have identified and described-issues of identity in chronic GI illness, medication as a double-edged sword, and survival strategies including hyper-vigilance about one's diet and bathroom mapping-highlight several major determinants affecting the quality of life experienced by persons with chronic GI disease.
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Numerous studies have demonstrated that leaf quality (e.g. content of secondary metabolites) is a major determinant affecting the distribution and abundance of herbivorous arthropods [3] [6].
General exclusion criteria were non-Caucasian origin and diseases, drugs, and other major determinants known to affect bone metabolism.
We determined how sociocultural and psychological determinants affect compliance.
Husband related risk factors and underlying determinants affect many women.
In addition, AD closely associates with the two major determinants of glucose homeostasis, affecting the natural history of hyperglycemia and its metabolic control.
27, 45 Recent studies in patients with type 2 diabetes have examined the hypothesis that insulin infusions may affect toll-like receptors (TLRs), major determinants of inflammatory response to viral, fungal, and bacterial pathogens.
The major determinants for the neuropsychological outcome are the functional integrity of surgically affected tissues, the functional reserve capacities of the remnant brain, the postoperative seizure outcome, as well as the quantitative and qualitative changes of antiepileptic drugs.
Since these pathways are major determinants of the methylation potential of the cell, our results could affect DNA methylation patterns, thereby influencing regulation of vital genes [ 39].
Major determinants of the deformities such as large relative bone loss of the affected bone, either shortening or a bone defect, malunion, or (infected) nonunion would be expected to affect the treatment outcome negatively.
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