Sentence examples for major deleterious consequences from inspiring English sources
One of the major deleterious consequences of a defective ETC is an ATP synthesis deficit that has a wide spread impact on most cellular functions.
This process has a major deleterious effect on the radiochemical yield but does not diminish the SA.
Because upstream enzymes are intermediary of multiple end products, even slightly deleterious amino acid changes in these enzymes could have major deleterious fitness consequences.
Both in vivo and ex vivo experimental studies have clearly demonstrated that severe lactic acidosis is associated with major deleterious vascular consequences, although these effects have not been formally demonstrated in humans.
Addressing elements of the syndrome that have multiple deleterious consequences is clearly of major importance.
These clinical observations are of major pathophysiological importance, as they highlight the deleterious consequences of OPA1 mutations not only for retinal ganglion cells, whose axons constitute the optic nerve, but also for other central neuronal populations, peripheral nerves and skeletal muscle.
The need for novel agents in the management of the metabolic syndrome is emphasized by the current lack of drugs to treat insulin resistance, one of the major components of the metabolic syndrome that has several deleterious consequences.
It is well known, however, that some mutations have no functional consequence, while others may have a major deleterious impact.
Controlling excessive immune stimulation with deleterious consequences for the host organs is a major strategy in severe infections.
In the context of the deleterious consequences of overconsumption it is interesting to note that the major causes of increased longevity in studies on calorically restricted primates (most recently [ 30]) is a reduction in the incidence of diabetes, cancer and cardiovascular disease relative to ad libitum fed controls.
Consequently, many businesses have invested in backup generators with deleterious consequences for investments in productive capital and scale economies [11].
