DOI: http://dx.doi.org/10.7554/eLife.02792.016 All strains also showed similar growth rates in rich media and no significant differences in sensitivity to hydroxyurea, methyl methanesulfonate (MMS), bleomycin, 4-nitroquinoline 1-oxide (4NQO), cycloheximide, and rapamycin, indicating no major defects with DNA replication or repair, protein synthesis, or the TOR signaling pathways.
Veneer splitting was the major defect with few knots or other defects found so the aggregate defect rule according to AS/NZS 2269.0 (2012) was not applied.
For minor defects membranes were used (lyophilized dura or alloplastic dura mater), whereas major defects were repaired with bone grafts (autografts, heterografts, or bone substitute material).
The government watchdog found that only five out of 19 regulatory assessments provided "good quality" analysis of the costs and benefits of proposed rules, while four did a downright bad job with "major defects" in their analysis.
The district later complained in court filings that both companies "not only consistently failed to meet deadlines, they also delivered shoddy software releases that are plagued with major defects or bugs".
Hippocampi with major defects were excluded from further analyses as they were few, could easily be identified, and would necessitate manual editing in order to be analysed, which was not the focus of the present study.
Gars 201R/201R homozygous mutants, however, only survive for a few weeks with major defects in the CNS observed.
The other 2 cases with major defects were normal at 1 week and 4 months but at 1 year, they had a major region without uptake.
Mouse embryos deficient in vinculin are small and die at day E10.5 with major defects in brain and heart development (Xu et al., 1998a).
Rescue is incomplete and variable at E14.5 E15.5, and some embryos still have major defects in liver structure with apoptotic nuclei both in hepatocytes and hematopoietic cells.
One headmaster, Andrew Seager, at Stratford school academy in east London, has complained about his new building, which was delivered with "700 snagging items and some major defects" and left the school with a £600,000 bill to complete works to the surrounding grounds.
