For minor defects membranes were used (lyophilized dura or alloplastic dura mater), whereas major defects were repaired with bone grafts (autografts, heterografts, or bone substitute material).
David Healy, professor of psychiatry in Bangor, Wales, who gave evidence in the Kilker case, said that at 4%, the rate of birth defects was double the normal rate, while the rate of major defects was 2% compared with 1%.
These and other major defects were first exposed by safety advocates who petitioned the government and by reporters in the tradition of Bob Irvin of The Detroit News, who wrote over 35 articles on Chevrolet engine mounts until General Motors agreed to recall 6.7 million vehicles in 1971.
Hippocampi with major defects were excluded from further analyses as they were few, could easily be identified, and would necessitate manual editing in order to be analysed, which was not the focus of the present study.
The other 2 cases with major defects were normal at 1 week and 4 months but at 1 year, they had a major region without uptake.
Moreover, both factors are localized to amacrine and ganglion cells (Zalutsky and Miller, 1990; Cristiani et al., 2002; Catalani et al., 2006) where major defects were found in Top2b KO/cKO retinas.
Data distribution and intensity of internal control probes including bisulfite I, II, hybridization, extension, specificity I, II, target removal were checked and no major defects were spotted for the QC.
It's a plausible-sounding theory whose major defect is the absence of supporting evidence.
Another major defect is the willingness of political authorities to replace manual police controls by adopting an ASE system to enforce the speed limits.
The second major defect was in cell migration where the sec7 - cells were slower and less persistent.
