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The phrase "major defects" is correct and usable in written English.
It is typically used to describe significant flaws or issues with something. For example: - The building had major defects in its foundation, making it unsafe to occupy. - The car had several major defects that the mechanic deemed necessary to fix before it could pass inspection. - Despite its aesthetic appeal, the home was found to have major defects in its plumbing system. - The report highlighted major defects in the company's financial management practices. - The new software had major defects that caused it to crash frequently.
Exact(59)
The current system, although far superior to what went before, has two major defects.
Rather that online reporting could offer a fresh start - the opportunity to correct major defects in the existing coverage of research.
One of the major defects of the ground zero design process thus far has been the nearly hysterical atmosphere it has generated.
Investigators found poor quality housing with some "major defects" because homes taken from previous suppliers were not properly checked.
The firm provided documents and emails showing that Bear Stearns routinely ignored major defects on loans it was purchasing and pooling so that it could preserve its relationship with mortgage originators.
While F.D.R. was a towering figure who defined the modern presidency, a superb communicator and an inspiring leader, Greenstein contends that his "chaotic organizational methods," his lack of vision and his intuitive approach to decision making were major defects.
It suffers from several major defects, the least of which happens to be the frequently made claim that it is inherently regressive.
Many of the approaches mentioned above suffer from three major defects.
Neither had evidence of major defects in the diaphragms confirmed by thorax CTs.
Yet the major defects of Mohist ethical thought lie precisely in how these ideas are handled.
The council said the campus would replace schools which were under occupied and showing major defects.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com